Research output
Publication
2026
Multiplexed intravascular molecular imaging using dual-channel near-infrared fluorescence integrated with optical coherence tomography
Scientific Reports, 2026; doi: 10.1038/s41598-026-75979-y
H2O2-and light-triggered MnO2-based nanoswitches for microenvironment reprogramming and photodynamic therapy of hypoxic atherosclerotic plaques
Journal of Nanobiotechnology, 2026; doi: 10.1186/s12951-026-05117-3
Eigenstate-selective entangled two-photon absorption in monolayer WSe2
Physical Review B, 2026; doi: 10.1103/wl4l-hyky
Lesion-Specific Prediction of Segmental Fractional Flow Reserve Using Deep Learning and Optical Coherence Tomography-Derived Features
2026; doi: 10.1253/circj.CJ-26-0020
▶ Video abstractOptical Coherence Tomography for Broad Spectrum of Thyroid Carcinoma: A Qualitative and Quantitative Analysis
Biomedical Engineering Letters, 2026; doi: 10.1007/s13534-026-00582-z
Label-free diagnosis across the thyroid nodule pathology spectrum using deep learning-enabled optical coherence tomography
Biomedical Optics Express, 2026; doi: 10.1364/BOE.591801
Single-objective two-photon oblique light sheet microscopy with a low repetition rate for 3D high-SNR imaging.
Photonics Research, 2026; doi: 10.1364/PRJ.584858
▶ Video abstractImpact of encoder-head installation errors and geometrical scale errors on angle self-calibration accuracy using four arbitrarily arranged encoder-heads.
Precision Engineering, 2026; doi: 10.1016/j.precisioneng.2026.05.003
Label-free multispectral fluorescence lifetime imaging enables non-invasive diagnosis of Alzheimer's disease in cerebral organoids.
Nano Today, 2026; doi: 10.1016/j.nantod.2026.103020
DMD-based adaptive lithography system for real-time substrate deformation compensation.
International Journal of Optomechatronics, 2026; doi: 10.1080/15599612.2026.2635849
Automated lipid detection in spectroscopic optical coherence tomography using a weakly supervised deep learning network.
Biomedical Optics Express, 2026; doi: 10.1364/BOE.585222
▶ Video abstract
2025
Programmable structured DUV illumination by coherent harmonic generation at crystalline solids for nanometer-resolution inspection of periodic samples.
PhotoniX, 2025; doi: 10.1186/s43074-025-00206-2
Chromatic optical coherence tomography for high-resolution deep tissue imaging.
Photonics Research, 2025; doi: 10.1364/PRJ.561513
▶ Video abstractBroadband fiber optic rotary joint for clinical multimodal optical coherence tomography.
IEEE Photonics Technology Letters, 2025; doi: 10.1109/LPT.2025.3601082
Targeted Theranostic Strategy for Atherosclerotic Plaques Using Intravascular Multimodal Imaging Techniques.
Journal of Lipid and Atherosclerosis, 2025; doi: 10.12997/jla.2025.14.3.258
Detrimental effects of advanced glycation end-products (AGEs) on a 3D skeletal muscle model in microphysiological system.
Biosensors & Bioelectronics, 2025; doi: 10.1016/j.bios.2025.117316
Reducing Multipath Artifacts in Double-Clad Fiber for Multimodal Endoscopic Optical Coherence Tomography.
Journal of Lightwave Technology, 2025; doi: 10.1109/JLT.2025.3576609
Self-supervised denoising of dynamic fluorescence images via temporal gradient-empowered deep learning.
PhotoniX, 2025; doi: 10.1186/s43074-025-00173-8
▶ Video abstractIntracoronary Structural-Molecular Imaging for Multitargeted Characterization of High-Risk Plaque: First-in-Human OCT-FLIm.
JAMA Cardiology, 2025; doi: 10.1001/jamacardio.2025.0928
▶ Video abstract- 2025 카이스트 대표 연구 성과 10선 선정 (https://me.kaist.ac.kr/news/news_020100.html?bmain=view&uid=1116)
- 동아사이언스 소개 (https://www.dongascience.com/ko/news/71540)
Nanometer-resolution white-light scanning interferometry for surface-profiling of hybrid bonding samples for advanced semiconductor packaging.
Applied Surface Science, 2025; doi: 10.1016/j.apsusc.2025.162466
Deep Learning-Based Saturation Compensation for High Dynamic Range Multispectral Fluorescence Lifetime Imaging.
IEEE Transactions on Biomedical Engineering, 2025; doi: 10.1109/TBME.2025.3548297
2024
Medical applications of endogenous fluorescence lifetime imaging.
Journal of Innovative Medical Technology, 2024; doi: 10.61940/jimt.240010
Real-time imaging assessment of stress-induced vascular inflammation using heartbeat-synchronized motion compensation.
Ateriosclerosis, Thrombosis, and Vascular Biology, 2024; doi: 10.1161/ATVBAHA.124.321566
Quantitative measurement of spatial distribution of effective refractive index induced by local electron concentration at a nano slit.
Nanophotonics, 2024; doi: 10.1515/nanoph-2024-0179
Multimodal imaging-assisted intravascular theranostic photoactivation on atherosclerotic plaque.
Circulation Research, 2024; 135(5);e114-132; doi: 10.1161/CIRCRESAHA.123.323970
A systematic review of deep learning-based denoising for low-dose computed tomography from a perceptual quality perspective.
Biomedical Engineering Letters, 2024; 1-21; doi: 10.1007/s13534-024-00419-7
In situ transfer of laser-induced graphene electronics for multifunctional smart windows.
Small Science. 2024; 240010; doi: 10.1002/smsc.202400010
Green manufacturing of electrically-tunable smart light-weight planar optics: a review
International Journal of Precision Enineering and Manufacturing-Green Technology, 2024; 1-23; doi: 10.1007/s40684-024-00621-z
Color volumetric imaging with high dynamic range based on parallel confocal detection.
IEEE Photonics Technology Letters. 2024; doi: 10.1109/LPT.2024.3406216
Swept-source Raman spectroscopy of chemical and biological materials.
Journal of Biomedical optics. 2024; 29(S2), S22703-S22703; doi: 10.1117/1.JBO.29.S2.S22703
An active geophone sensor with optimized state variable filter for measuring low-band frequencies.
Precision Engineering and Manufacturing. 2024; 25(5):981-993; doi: 10.1007/s12541-024-00963-3
Macrophage-mannose-receptor-targeted photoactivatable agent for in vivo imaging and treatment of atherosclerosis
International Journal of Pharmaceutics 2024; 10:654:123951; doi: 10.1016/j.ijpharm.2024.123951
2023
Imaging peritoneal blood vessels through optical coherence tomography angiography for laparoscopic surgery
Journal of Biophotonics 2023; e202300221; doi: 10.1002/jbio.202300221
Massively parallel electro-optic sampling of space-encoded optical pulses for ultrafast multi-dimensional imaging
Light: Science & Applications 2023; 12:44; doi: 10.1038/s41377-023-01077-7
SNR enhanced high-speed two-photon microscopy using a pulse picker and time gating detection
Scientific Reports 2023; 13.1:14244; doi: 10.1038/s41598-023-41270-7
Feasibility and safety of non-contrast optical coherence tomography imaging using hydroxyethyl starch in coronary arteries
Scientific Reports 2023; 13.1:13818; doi: 10.1038/s41598-023-40363-7
Ultra-thin light-weight laser-induced-graphene (LIG) diffractive optics
Light: Science & Applications 2023; 12.1: 146; doi: 10.1038/s41377-023-01143-0
Label-Free Characterization of Atherosclerotic Plaques Via High-Resolution Multispectral Fluorescence Lifetime Imaging Microscopy
Arteriosclerosis, Thrombosis and Vascular Biology 2023; 43: 1295-1307; doi: 10.1161/ATVBAHA.123.319339
Deep learning-based image enhancement in optical coherence tomography by exploiting interference fringe
Communications Biology 2023; 6: 463; doi: 10.1038/s42003-023-04846-7
2022
Histological classification of atherosclerotic arteries using high-speed confocal Raman microscopy with machine learning
Journal of Biophotonics 2022; e202200243; doi: 10.1002/jbio.202200243
Imaging Technologies for Microfluidic Biochips
BioChip Journal 2022; 16: 255-269; doi: 10.1007/s13206-022-00067-y
Method for improving the speed and pattern quality of a DMD maskless lithography system using a pulse exposure method
Optics Express 2022; 30(13): 22487-22500; doi: 10.1364/OE.460780
Lateral image reconstruction of optical coherence tomography using one‐dimensional deep deconvolution network
Lasers in Surgery and Medicine 2022; 1-12; doi: 10.1002/lsm.23543
Highly enhanced macrophage-driven inflammatory signatures on giant coronary artery aneurysms: a 3D-rendered 18F-FDG-PET/CT imaging assessment
European Heart Journal 2022; 43(6): 541-542; doi: 10.1093/eurheartj/ehab463
2021
Comprehensive assessment of high-risk plaques by dual-modal imaging catheter in coronary artery
JACC: Basic to Translational Science 2021; 6(12): 948-960; doi: 10.1016/j.jacbts.2021.10.005
Macrophage targeted heranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque
Theranostics 2021; 11(18): 8874-8893; doi: 10.7150/thno.59759
Targeted theranostic photoactivation on atherosclerosis
Journal of Nanobiotechnology 2021; vol 19, 338; doi: 10.1186/s12951-021-01084-z
Robust autoflcusing for scanning electron microscopy based on a dual deep learning network
Scientific Reports 2021; vol 11, 20933; doi: 10.1038/s41598-021-00412-5
Multimodal microscopy for the simultaneous visualization of five different imaging modalities using a single light source
Biomedical Optics Express 2021; vol 12, Issue 9, pp. 5452-5469; doi: 10.1364/BOE.430677
Three-dimensional confocal reflectance microscopy for surface metrology.
Measurement Science and Technology 2021; 32(24) 102002; doi: 10.1088/1361-6501/ac04df
Utilization potential of intraluminal optical coherence tomography for the Eustachian tube.
Scientific Reports 2021; 11:6219; doi: 10.1038/s41598-021-85634-3
Color three-dimensional imaging based on patterned illumination using a negative pinhole array
Optics Express 2021; 29(5):6509-6522; doi: 10.1364/OE.416999
Stress-associated neurobiological activity is linked with acute plaque instability via enhanced macrophage activity: a prospective serial 18F-FDG-PET/CT imaging assessment.
European Heart Journal 2021; DOI 10.1093/eurheartj/ehaa1095
Label-free multimodal microscopy using a single light source and detector for biological imaging.
Optics Letters 2021; 46(4):0892-0895; doi: 10.1364/OL.415938
2020
Long journey of intravascular imaging: What and how to look at the atheroma in coronary artery
JACC: Cardiovascular imaging 2020; DOI 10.1016/j.jcmg.2020.11.015
In vivo imaging of reactive oxygen species (ROS)-producing pro-inflammatory macrophages in murine carotid atheromas using a CD44-targetable and ROS-responsive nanosensor
Journal of Industrial and Engineering Chemistry 2020; Vol 92, 158-166
Astigmatism-corrected endoscopic imaging probe for optical coherence tomography using soft lithography.
Optics Letters 2020; 45(17):4867-4870
Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure.
Scientific Reports 2020; 10:9248
Large-area thickness measurement of transparent multi-layer films based on laser confocal reflection sensor.
Measurement 2020; 153:107390
Annular-beam dual-detection confocal reflectance microscopy for high-speed 3D surface profiling with an extended volume.
Measurement Science and Technology 2020; 31(4):045403
2019
High-speed line-scan confocal Raman microscope with enhanced diffraction efficiency.
Measurement Science and Technology 2019; 31(2):025203
High-speed color three-dimensional measurement based on parallel confocal detection with a focus tunable lens.
Optics Express 2019;27(20):28466-28479
Emulating endothelial dysfunction by implementing early atherosclerotic microenvironment within a microfluidic chip.
Lab on a Chip 2019; 19:3664-3677
Rapid histologic diagnosis using quick fluorescence staining and tissue confocal microscopy.
Microscopy Research and Technique. 2019;1-6.
2018
Rapid tissue histology using multichannel confocal fluorescence microscopy with focus tracking.
Quantitative Imaging in Medicine and Surgery 2018;8(9):884-893.
Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging.
Scientific Reports 2018;8:14561.
Real-time visualization of two-photon fluorescence lifetime imaging microscopy using a wavelength-tunable femtosecond pulsed laser.
Biomedical Optics Express 2018;9(7):3449-3463.
Multipoint scanning dual-detection confocal microscopy for fast 3D volumetric measurement
Journal of Microscopy 2018;270(2):200-209.
Multispectral analog-mean-delay fluorescence lifetime imaging combined with optical coherence tomography.
Biomedical Optics Express 2018;9(4):1930-1947.
Intravascular Optical Molecular Imaging of a Macrophage Subset Within Intraplaque Hemorrhages.
JACC:Cardiovascular Imaging 2018;11(2):371-72.
Spectroscopic Optical Coherence Tomography: A Review of Concepts and Biomedical Applications.
Applied Spectroscopy Reviews 2018;53(2-4),91-111.
Therpaeutic Effects of Targeted PPARy Activation on Inflamed High-Risk Plaques Assessed by Serial Optical Imaging In Vivo.
Theranostics 2018;8(1):45-60.
2017
Removal of back-reflection noise at ultrathin imaging probes by the single-core illumination and wide-field detection.
Scientific Reports;7:6524.
Inflammatory coronary ectasia identified by three-dimensional volume rendering of 18F-Fluorodeoxyglucose PET/CT.
EuroIntervention 2017;13:e227.
Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter.
Optics Letters 2017;42(3):379-382.
2016
High-speed time-resolved laser-scanning microscopy using the line-to-pixel referencing method.
Applied Optics 2016;55(32):9033-9041.
Compact fiber optic dual-detection confocal displacement sensor.
Applied Optics 2016;55(27):7631-7635.
Characterization of lipid-rich plaque using spectroscopic optical coherence tomography.
Journal of Biomedical Optics 2016;21(7):075004.
Automated detection of vessel lumen and stent struts in intravascular optical coherence tomography to evaluate stent apposition and neointimal coverage.
Medical Physics 2016;43(3):1662-1675.
Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors.
Scientific Reports 2016;6:22608
High-speed 3-D measurement with a large field of view based on direct-view confocal microscope with an electrically tunable lens.
Optics Express 2016;24(4):3806-3816.
Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural/molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery.
European Heart Journal 2016;37(37):2833-2844
Design and fabrication of an optical probe with a phase filter for extended depth of focus.
Optics Express 2016;24(2):1037-1044.
2015
Concurrent Carotid Inflammation in Acute Coronary Syndrome as Assessed by 18F-FDG PET/CT: A Possible Mechanistic Link for Ischemic Stroke.
Journal of Stroke and Cerebrovascular Diseases 2015;24(11):2547-2554
Multimodal confocal hyperspectral imaging microscopy with wavelength sweeping source.
Measurement Science and Technology 2015;26:025701
A bi-directional assessment of spontaneous coronary artery dissection by three-dimensional flythrough rending of optical coherence tomography images.
European Heart Journal 2015;10.1093:498
2014
High speed 3D surface profile without axial scanning: dual-detection confocal reflectance microscopy.
Measurement Science and Technology 2014;25:125403
Diagnostic Fiber-based Optical Imaging Catheters.
Biomedical Engineering Letter 2014;4:239-249.
Fully Integrated High-Speed Intravascular Optical Coherence Tomography/Near-Infrared Fluorescence Structural/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence-Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atheromata in Coronary-Sized Vessels.
Circulation: Cardiovascular Interventions 2014;DOI:10.1161/CIRCINTERVENTIONS.114.001498
– YTN 사이언스 투데이 2014.8.6.(link)
– 중앙일보(link), 이데일리(link), 파이낸셜뉴스(link) 등 언론 소개.
Fiber-optic raster scanning two-photon endomicroscope using a tubular piezoelectric actuator.
Journal of Biomedical Optics 2014;19(6):066010.
Three-Dimensional Intravascular Optical Coherence Tomography Rendering Assessment of Spontaneous Coronary Artery Dissection Concomitant With Left Main Ostial Critical Stenosis.
JACC: Cardiovascular Interventions 2014;7(6):e57-e59.
A near-infrared confocal scanner.
Measurement Science and Technology 2014;25:065403.
Coronary Stent Fracture Complicated Multiple Aneurysms Confirmed by 3-Dimensional Reconstruction of Intravascular-Optical Coherence Tomography in a Patient Treated With Open-Cell Designed Drug-Eluting Stent.
Circulation 2014;129:e24-e27.
2013
Dual-detection confocal fluorescence microscopy: fluorescence axial imaging without axial scanning.
Optics Express 2013;21(15):17839-17848.
– Selected and published in Virtual Journal of Biomedical Optics (VJBO), VJBO 2013;8(8).
– Featured in Laser Focus World, September 2013.
Endoscopic focal modulation microscopy.
Journal of Microscopy 2013;250(2):116-121.
Chromatic confocal microscopy with a novel wavelength detection method using transmittance.
Optics Express 2013;21(5):6286-6294.
– Selected and published in Virtual Journal of Biomedical Optics (VJBO), VJBO 2013;8(4).
2012
Design and analysis of a cross-type structured-illumination confocal microscope for high speed and high resolution.
Measurement Science and Technology 2012;23:105403.
Evaluation of optical reflectance techniques for imaging of alveolar structure.
Journal of Biomedical Optics 2012;17(7):071303.
Compensation of motion artifacts in intracoronary optical frequency domain imaging and optical coherence tomography.
International Journal of Cardiovascular Imaging 2012;28:1299-1304:(DOI:10.1007/s10554-011-9953-8).
2011
Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus.
Photonics Letters of Poland 2011;3(4):144-146.
Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo.
Nature Medicine 2011:17(12):1680-1684.
– KBS, YTN, 매일경제, 국민일보, New Scientist, chemistry World, MedicalXpress 등 국내외 언론 다수 소개.
– BRIC 한국을 빛낸 사람들 선정.
Reflectance confocal microscopy for the diagnosis of eosinophilic esophagitis: a pilot study conducted on biopsy specimens.
Gastrointestinal Endoscopy 2011;74(5):992-1000.
Comprehensive volumetric confocal microscopy with adaptive focusing.
Biomedical Optics Express 2011;2(6):1412-1422.
2010
Compensation of motion artifacts in catheter-based optical frequency domain imaging.
Optics Express 2010;18(11):11418-27.
Comprehensive imaging of gastroesophageal biopsy samples by spectrally encoded confocal microscopy.
Gastrointestinal Endoscopy 2010;71(1):35-43.
2004–2009
Aberration corrected beam scanning stimulated emission depletion microscopy.
International Journal of Optomechatronics 2008;2(4):401-412
Method for the improvement of lateral resolution in stimulated emission depletion microscopy using a pupil filter.
Measurement Science and Technology 2007;18:N61-64.
Alignment of laboratory-scale soft x-ray microscope using laser plasma.
Japanese Journal of Applied Physics 2007;46(1):394-399.
Confocal scanning microscopy: a high-resolution nondestructive surface profiler.
International Journal of Precision Engineering and Manufacturing 2006;7(4):3-7.
Measurement and restoration of the point spread function of fluorescence confocal microscopy.
Journal of Microscopy 2006;221(3):172-176.
Lateral resolution enhancement in confocal self-interference microscopy with commercial calcite plate.
Journal of Optical Society of Korea 2005;9(1):32-35.
Measurement of sub-micrometer features based on the topographic contrast using reflection confocal microscopy.
Journal of Optical Society of Korea 2005;9(1):26-31.
Advanced technique for bio-chemical analysis : confocal scanning microscope.
Journal of the KSME 2005;45(3):49-51 (invited review)
Error analysis and alignment tolerancing for confocal scanning microscope using Monte Carlo method.
Journal of Korea Society Precision Engineering 2004;21(2):92-99.